Sodium Hydroxide → [4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

HRID 460026노트

반응식

HRID 460026 반응식
C([O:3][C:4](=[O:22])[CH2:5][C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:8][C:7]=1[CH3:21])C.[OH-].[Na+]>CO>[CH3:21][C:7]1[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=2)[S:10][C:6]=1[CH2:5][C:4]([OH:22])=[O:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 17972170Ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate2회

생성물 1

HCID 17972178[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate (intermediate 13, 0.5 g) in methanol (5 ml) was added 2M sodium hydroxide solution (3 ml). The resulting suspension was stirred at room temperature for 40 minutes, before the solvent was removed in vacuo. The residue was diluted with water (5 ml) acidified (2M hydrochloric acid) and the product extracted twice with ethyl acetate. The combined organic extracts were dried (magnesium sulfate), filtered and evaporated to give the title compound as a yellow solid.

후처리

  1. customwas removed in vacuo
  2. additionThe residue was diluted with water (5 ml)
  3. extractionthe product extracted twice with ethyl acetate
  4. dry with materialThe combined organic extracts were dried (magnesium sulfate)
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-ae2ceac6b2e347b3bf9e54495ec1ae92
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196107B2

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