Ammonia → 1-(1-Methyl-1H-indol-4-yl)ethan-1-amine

HRID 460152노트

반응식

HRID 460152 반응식
[N:1]1C=CC=C(C(N)C)C=1.[CH3:10][N:11]1[C:19]2[C:14](=[C:15]([C:20](=O)[CH3:21])[CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12]1.N.CO.C([BH3-])#N.[Na+]>C(O)(=O)C>[CH3:10][N:11]1[C:19]2[C:14](=[C:15]([CH:20]([NH2:1])[CH3:21])[CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12]1

참가 물질

7

반응물 5

HCID 222AmmoniaHCID 887MethanolHCID 27716881-(Pyridin-3-yl)ethan-1-amineHCID 5003444Sodium cyanoborohydrideHCID 149872881-(1-Methyl-1H-indol-4-yl)ethanone

생성물 1

HCID 208032231-(1-Methyl-1H-indol-4-yl)ethan-1-amine수율 48%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The title compound was prepared by the same procedure for preparing 1-pyridin-3-yl-ethylamine from 1-(1-methyl-1H-indol-4-yl)-ethanone (1.75 g, 10 mmol), 2 M ammonia solution in methyl alcohol (25 mL, 50 mmol, Aldrich), acetic acid (15 mL, J. T. Baker) and sodium cyanoborohydride (2.5 g, 40 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, 2 M ammonia solution in methyl alcohol/ethyl acetate 1/10) in form as light yellow oil in 48% yield (0.83 g, 4.8 mmol).

후처리

  1. customThe title compound was purified by column chromatography (silica gel, 2 M ammonia solution in methyl alcohol/ethyl acetate 1/10) in form as light yellow oil in 48% yield (0.83 g, 4.8 mmol)

출처 및 근거

ORD 기록
ord-69d63a88b7634aa5ad6c0add816cb250
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196102B2

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