Ethyl 2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-8-nonenoate → 10-[3,17beta-Dihydroxyestra-1,3,5(10)-trien-7alpha-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)decanoic acid

HRID 460473

반응식

HRID 460473 반응식
C[O:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@H:8]([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C@@H:12]([OH:21])[CH2:11][CH2:10]4)[C@H:7]([CH2:22][CH:23]=[CH2:24])[CH2:6][C:5]=2[CH:4]=1.[F:25][C:26]([F:52])([C:42]([F:51])([F:50])[C:43]([F:49])([F:48])[C:44]([F:47])([F:46])[F:45])[CH2:27][CH2:28][CH:29]([CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]C=C)[C:30]([O:32]CC)=[O:31]>>[OH:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@H:8]([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C@@H:12]([OH:21])[CH2:11][CH2:10]4)[C@H:7]([CH2:6][CH2:5][CH2:4][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][CH:29]([CH2:28][CH2:27][C:26]([F:25])([F:52])[C:42]([F:50])([F:51])[C:43]([F:48])([F:49])[C:44]([F:45])([F:47])[F:46])[C:30]([OH:32])=[O:31])[CH2:22][C:23]=2[CH:24]=1

참가 물질

3

반응물 2

HCID 12048018Ethyl 2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-8-nonenoateHCID 694148073-Methoxy-7alpha-(2-propenyl)estra-1,3,5(10)-trien-17beta-ol

생성물 1

HCID 5331853010-[3,17beta-Dihydroxyestra-1,3,5(10)-trien-7alpha-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)decanoic acid

실험 절차

Starting with the 3-methoxy-7α-(2-propenyl)estra-1,3,5(10)-trien-17β-ol prepared in Example 13 and ethyl 2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-8-nonenoate prepared separately, the same procedure as shown in Example 13 was repeated to give 10-[3,17β-dihydroxyestra-1,3,5(10)-trien-7α-yl]-2-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)decanoic acid.

후처리

  1. customprepared separately

출처 및 근거

ORD 기록
ord-97a653d0ace3423e9958c9e09aa5695b
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196081B2

연결된 노트

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