Phosphorus tribromide → HCID 22759278, 화합물

HRID 460845노트

반응식

HRID 460845 반응식
P(Br)(Br)[Br:2].[C:5]([O:8][CH:9]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:10]#[C:11][CH2:12]O)(=[O:7])[CH3:6]>CCOCC>[C:5]([O:8][CH:9]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:10]#[C:11][CH2:12][Br:2])(=[O:7])[CH3:6]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 22759281HCID 22759281, 화합물

생성물 1

HCID 22759278HCID 22759278, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Phosphorus tribromide (10.6 g., 0.039 mole) is added dropwise during 15 minutes to a solution of 4-acetoxy-5-(4-fluorophenoxy)-2-pentyn-1-ol (25.1 g., 0.10 mole) in ether (80 ml.). The resulting solution is stirred at room temperature for 1 hour and then heated at reflux for 30 minutes. The solution is poured into 100 ml. of ice water. The organic layer is separated, washed with water and dried over Na2SO4. The solvent is evaporated under reduced pressure to leave the title compound as a light yellow oil.

후처리

  1. temperatureheated
  2. temperatureat reflux for 30 minutes
  3. additionThe solution is poured into 100 ml
  4. customThe organic layer is separated
  5. washwashed with water
  6. dry with materialdried over Na2SO4
  7. customThe solvent is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-9f2a9b2d49534898a3dee23bed80b90a
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061643

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