Benzyl Alcohol → HCID 22759231, 화합물

HRID 460859노트

반응식

HRID 460859 반응식
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:11]([CH:14]([CH2:26][CH2:27][CH2:28][CH:29]1[O:31][CH2:30]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=[O:13])[CH3:12]>O>[C:11]([CH:14]([CH2:26][CH2:27][CH2:28][CH:29]([OH:31])[CH2:30][O:10][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][C:25]1[CH:8]=[CH:9][CH:4]=[CH:5][CH:6]=1)=[O:22])(=[O:13])[CH3:12]

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 22759269HCID 22759269, 화합물

생성물 1

HCID 22759231HCID 22759231, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Sodium hydride (0.04 mole) is added in portions with stirring to benzyl alcohol (25 ml.). To the resulting solution, ethyl 8-acetyl-12,13-epoxytridecanoate (0.02 mole) is added and the mixture allowed to stand 18 hours at 55°-60°. The reaction mixture is then cooled and treated with water. The organic layer is separated and dried over magnesium sulfate. Excess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure. The residue consists mainly of the title compound and is used in the next step without purification.

후처리

  1. temperatureThe reaction mixture is then cooled
  2. customThe organic layer is separated
  3. dry with materialdried over magnesium sulfate
  4. customExcess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure
  5. customis used in the next step without purification

출처 및 근거

ORD 기록
ord-dc7725c771974fbe941a4793432df51b
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061643

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