Hydrochloric Acid → 4-Bromo-3-sulfamoylbenzoyl chloride

HRID 461150

반응식

HRID 461150 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[ClH:15]>S(Cl)(Cl)=O.O1CCOCC1>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 5542164-Bromo-3-sulfamoylbenzoic acid

생성물 1

HCID 213166124-Bromo-3-sulfamoylbenzoyl chloride

시약·촉매·용매 2

HCID 24386Thionyl Chloride용매HCID 312751,4-Dioxane용매

실험 절차

10 g of 4-bromo-3-sulfamoylbenzoic acid were heated under reflux in a mixture of 80 ml of thionyl chloride and 50 ml of dioxane until HCl had completely developped. Then, the reaction mixture was concentrated under reduced pressure to 40 ml, 200 ml of petroleum ether were added and the crystals were filtered off. Melting point: 138° C (decomposition).

후처리

  1. concentrationThen, the reaction mixture was concentrated under reduced pressure to 40 ml, 200 ml of petroleum ether
  2. additionwere added
  3. filtrationthe crystals were filtered off

출처 및 근거

ORD 기록
ord-22347022073d468bbc2ecf5c668e254f
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061761

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