2,6-Lutidine → 1-Chloro-3-triphenylmethoxyhexane

HRID 461272노트

반응식

HRID 461272 반응식
[Cl:1][CH2:2][CH2:3][CH:4]([OH:8])[CH2:5][CH2:6][CH3:7].[C:9]1([C:15](Br)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.N1C(C)=CC=CC=1C.ClC1C=CC=CC=1>O>[Cl:1][CH2:2][CH2:3][CH:4]([O:8][C:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:5][CH2:6][CH3:7]

참가 물질

6

반응물 4

HCID 79372,6-LutidineHCID 7964ChlorobenzeneHCID 11692BromotriphenylmethaneHCID 189210071-Chlorohexan-3-ol

생성물 1

HCID 203810131-Chloro-3-triphenylmethoxyhexane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A stirred solution of 27.3 g. (0.20 moles) of 1-chloro-3-hexanol, 77.6 g. (0.24 moles) of triphenylmethyl bromide, 30,0 g. (0.28 moles of 2,6-lutidine, and 200 ml. of chlorobenzene is heated at 95° C. for 1 hour. The cooled mixture is treated with water, and the organic phase is washed successively with water and saturated sodium chloride solution. The solution is dried over magnesium sulfate and concentrated. Column chromatography of the residue on Florisil affords the subject compound as an oil, ν max. 1600, 1030, and 705 cm-1 (triphenylmethoxy group).

후처리

  1. washthe organic phase is washed successively with water and saturated sodium chloride solution
  2. dry with materialThe solution is dried over magnesium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-51b14a3083bb48db93c36097f9292ae6
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04061672

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