1,2-Dichloroethane → Benzonitrile, 4-(5-heptyl-2-pyrimidinyl)-

HRID 461307노트

반응식

HRID 461307 반응식
C([C:8]1[CH:13]=[CH:12][N:11]=[C:10]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=O)=[CH:16][CH:15]=2)[N:9]=1)CCCCCC.[CH2:23](Cl)[CH2:24]Cl.P(Cl)(Cl)(Cl)=O>CCOCC>[CH2:16]([C:13]1[CH:12]=[N:11][C:10]([C:14]2[CH:15]=[CH:16][C:17]([C:18]#[N:20])=[CH:21][CH:22]=2)=[N:9][CH:8]=1)[CH2:15][CH2:14][CH2:22][CH2:21][CH2:23][CH3:24]

참가 물질

5

반응물 3

HCID 111,2-DichloroethaneHCID 24813Phosphorus oxychlorideHCID 538442864-(4-n-Heptylpyrimid-2-yl)benzoic acid amide

생성물 1

HCID 108846Benzonitrile, 4-(5-heptyl-2-pyrimidinyl)-

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

1.9 g. of 4-(4-n-heptylpyrimid-2-yl)benzoic acid amide are left for 80 minutes under reflux in a mixture of 40 ml. of ethylene chloride and 0.63 ml. of phosphorus oxychloride, with stirring. The reaction mixture, diluted with ether, is washed with 2N sodium hydroxide solution and then with water until neutral. After evaporation of the organic phase, drying over sodium sulfate, 1.9 g. of 5-n-heptyl-2-(4-cyanophenyl)-pyrimidine result, which are distilled in a high vacuum, having a m.p. of 44.2°-44.7°; cl.p. 50.1°-50.4°.

후처리

  1. temperatureunder reflux in a mixture of 40 ml
  2. washis washed with 2N sodium hydroxide solution
  3. customAfter evaporation of the organic phase
  4. dry with materialdrying over sodium sulfate, 1.9 g

출처 및 근거

ORD 기록
ord-aa5edd4b8d9c45928ad767ebc30ae839
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04062798

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