1-Piperazinecarboxylic acid, ethyl ester → 2-(4-Carbethoxypiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

HRID 461332노트

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HRID 461332 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4](Cl)[N:3]=1.[CH3:17][CH2:18][O:19][C:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)=[O:21]>>[C:20]([N:22]1[CH2:27][CH2:26][N:25]([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=2)[CH2:24][CH2:23]1)([O:19][CH2:18][CH3:17])=[O:21]

참가 물질

3

반응물 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamine

생성물 1

HCID 133706732-(4-Carbethoxypiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

반응 조건

온도
100 °C

실험 절차

In a reaction vessel equipped with stirrer, thermometer and drying tube was charged 60 ml. of isoamyl alcohol, 10 g. (0.042 mole) of 4-amino-2-chloro-6,7-dimethoxyquinazoline (prepared as described in U.S. Pat. No. 3,511,836) and 7.3 g. (0.047 mole) ethyl-N-piperazinocarboxylate (Aldrich Chemical Co.). The mixture was heated at 100° C. for 3 hours and allowed to stand overnight at room temperature. The mixture was diluted with 120 ml. of isoamyl alcohol and filtered to obtain 14.3 g. (94%) of the hydrochloride salt of the title compound, which melted sharply at 295° C.

후처리

  1. customIn a reaction vessel equipped with stirrer
  2. customthermometer and drying tube
  3. additionwas charged 60 ml
  4. additionThe mixture was diluted with 120 ml
  5. filtrationof isoamyl alcohol and filtered
  6. customto obtain 14.3 g

출처 및 근거

ORD 기록
ord-7b4e09c206f44fffa65c05624613a57d
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04062844

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