Carbon Disulfide → 1-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

HRID 461383

반응식

HRID 461383 반응식
[CH:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[C:19](=S)=[S:20].C1(N=C=NC2CCCCC2)CCCCC1>C(OCC)(=O)C>[CH:1]1([N:11]=[C:19]=[S:20])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 6348Carbon DisulfideHCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 180661,2,3,4-Tetrahydro-1-naphthylamine

생성물 1

HCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a stirred solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthylamine in ethyl acetate is added 0.01 mole of triethylamine and 0.011 mole of carbon disulfide. The mixture is stirred about one hour and then 0.01 mole of dicyclohexyl carbodiimide is added. The mixture is stirred overnight, and the mixture filtered to remove solid dicyclohexylthiourea. The filtrate is evaporated, and the residue is purified by dry column chromatography to give 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate.

후처리

  1. stirringThe mixture is stirred overnight
  2. filtrationthe mixture filtered
  3. customto remove solid dicyclohexylthiourea
  4. customThe filtrate is evaporated
  5. customthe residue is purified
  6. customby dry column chromatography

출처 및 근거

ORD 기록
ord-3365a2d755984063967f6f5f5f27ce05
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04062856

연결된 노트

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