Chlorine → 2,6-Dichloro-4-(dichlorofluoromethyl)pyridine

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([C:8](Cl)([Cl:10])[Cl:9])[CH:5]=[C:4]([Cl:12])[N:3]=1.[Sb](F)(F)[F:14].ClCl>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([Cl:10])([Cl:9])[F:14])[CH:5]=[C:4]([Cl:12])[N:3]=1

참가 물질

반응물 3

HCID 24526Chlorine

HCID 24554Antimony trifluoride

HCID 897822,6-Dichloro-4-(trichloromethyl)pyridine

생성물 1

HCID 205177022,6-Dichloro-4-(dichlorofluoromethyl)pyridine

실험 절차

A mixture containing 138.5 grams (0.522 mole) of 2,6-dichloro-4-(trichloromethyl)pyridine and 34 grams (0.187 mole) of Antimony trifluoride was heated to 80°-84° C. and maintained under agitation for 23 minutes. During this step, a slow stream of chlorine gas was passed over the surface of the reaction mixture. The reaction mixture was steam distilled and the crude 2,6- dichloro-4-(dichlorofluoromethyl)pyridine product was purified by fractionation. The product had a boiling point of 74°-76° C. at 1.0 millimeter of mercury.

후처리

temperaturewas heated to 80°-84° C.
temperaturemaintained under agitation for 23 minutes
distillationdistilled
customthe crude 2,6- dichloro-4-(dichlorofluoromethyl)pyridine product was purified by fractionation

출처 및 근거

ORD 기록: ord-de387339e07e463cbf8028122199f01b
출처 데이터셋: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04062962

반응 노트

불러오는 중…