Methyl isothiocyanate → 2-(Methylaminothioxomethyl)-N-[3-[3-(1-piperidinylmethyl)phenoxy]-propyl]-hydrazine carboxamide

HRID 4616

반응식

HRID 4616 반응식
[CH3:1][N:2]=[C:3]=[S:4].[N:5]1([CH2:11][C:12]2[CH:13]=[C:14]([CH:24]=[CH:25][CH:26]=2)[O:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([NH:22][NH2:23])=[O:21])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>C1COCC1>[CH3:1][NH:2][C:3](=[S:4])[NH:23][NH:22][C:20]([NH:19][CH2:18][CH2:17][CH2:16][O:15][C:14]1[CH:24]=[CH:25][CH:26]=[C:12]([CH2:11][N:5]2[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]2)[CH:13]=1)=[O:21]

참가 물질

4

반응물 2

HCID 11167Methyl isothiocyanateHCID 13657330N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarboxamide

생성물 1

HCID 136573442-(Methylaminothioxomethyl)-N-[3-[3-(1-piperidinylmethyl)phenoxy]-propyl]-hydrazine carboxamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

0.5 g (6.6 mmol) of methylisothiocyanate are added to 1.0 g (3.3 mmol) of N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carboxamide in 20 ml of THF and the mixture is stirred at room temperature for 12 hours. The precipitate obtained is filtered off and recrystallised from ethanol. The analytical values are summarized in Table I.

후처리

  1. customThe precipitate obtained
  2. filtrationis filtered off
  3. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-43d9b13e76d64c13a9297ad2f6e9042c
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727081

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