Hydrochloric Acid → 2-(2-(1-Ethylpiperidin-2-yl)ethyl)aniline

HRID 461910노트

반응식

HRID 461910 반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[NH:17]C=O)[CH3:2].Cl>CO>[NH2:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH2:10][CH2:9][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][N:3]1[CH2:1][CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 20559971N-{2-[2-(1-Ethylpiperidin-2-yl)ethyl]phenyl}formamide

생성물 1

HCID 205599832-(2-(1-Ethylpiperidin-2-yl)ethyl)aniline

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1-ethyl-2-(2-formamidophenethyl)piperidine (27.6 g., 0.11 mole), methanol (450 ml.) and concentrated HCl (100 ml.) allowed to stand for 24 hr. provides 2-(2-aminophenethyl)-1-ethylpiperidine, purified by distillation, yield 17.72 g. (69%), b.p. 107°-128° C./0.1 Torr, nD30° 1.5510.

후처리

  1. distillationprovides 2-(2-aminophenethyl)-1-ethylpiperidine, purified by distillation, yield 17.72 g

출처 및 근거

ORD 기록
ord-f427d35201fa4899baf6b9f14bd54f23
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064254

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