Dimethyl Sulfoxide → HCID 21392721, 화합물

HRID 461992노트

반응식

HRID 461992 반응식
S(O[CH2:12][C:13]12[CH2:20][CH2:19][C:16]([CH3:21])([CH2:17][CH2:18]1)[CH2:15][CH2:14]2)(C1C=CC(C)=CC=1)(=O)=O.[C-:22]#[N:23].[Na+].CS(C)=O>C(Cl)Cl>[CH3:21][C:16]12[CH2:15][CH2:14][C:13]([CH2:12][C:22]#[N:23])([CH2:18][CH2:17]1)[CH2:20][CH2:19]2

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 8929Sodium CyanideHCID 13409934HCID 13409934, 화합물

생성물 1

HCID 21392721HCID 21392721, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The mixture containing 0.065 mole of 4-methylbicyclo[2.2.2]oct-1-yl methanol tosylate, 0.1 mole of sodium cyanide, and 100 ml. of dimethyl sulfoxide is stirred at 70° C for 4 hours and then poured into 500 ml. of methylene chloride. The organic phase is then washed four times with water, separated and dried with anhydrous magnesium sulfate and filtered. The filtrate is then evaporated under vacuum affording an oil which is then chromatographed on silica gel eluting with 10% ethyl acetate-90%, vol., hexane affording 4-methylbicyclo[2.2.2]oct-1-yl acetonitrile.

후처리

  1. additionpoured into 500 ml
  2. washThe organic phase is then washed four times with water
  3. customseparated
  4. dry with materialdried with anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customThe filtrate is then evaporated under vacuum
  7. customaffording an oil which
  8. customis then chromatographed on silica gel eluting with 10% ethyl acetate-90%, vol., hexane

출처 및 근거

ORD 기록
ord-a5b825c35c3b4e0cb867ed122f472847
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064258

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