(4-Aminophenoxy)benzene → 1-(4-Phenoxyphenyl)piperazine

HRID 462007

반응식

HRID 462007 반응식
Br[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]Br.[O:8]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([O-])([O-])=O.[Na+].[Na+]>CO>[O:8]([C:15]1[CH:16]=[CH:17][C:18]([N:19]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:20][CH:21]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 8764(4-Aminophenoxy)benzeneHCID 10340Sodium CarbonateHCID 415719Bis(2-bromoethyl)amine

생성물 1

HCID 30173561-(4-Phenoxyphenyl)piperazine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 62.4 parts of bis-(β-bromoethyl)amine dihybromide in 160 parts of methanol there were added 37 parts of para-phenoxyaniline. The mixture was refluxed for 10 hours. 10.6 parts of Na2CO3 were then added and the reaction mixture was refluxed for a further 10 hours. After cooling, the precipitate was filtered off, washed with 80 parts of methanol and dried.

후처리

  1. temperatureThe mixture was refluxed for 10 hours
  2. temperaturethe reaction mixture was refluxed for a further 10 hours
  3. temperatureAfter cooling
  4. filtrationthe precipitate was filtered off
  5. washwashed with 80 parts of methanol
  6. customdried

출처 및 근거

ORD 기록
ord-2368a7cc6aa643bf82c15e20288aef90
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04064245

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