(4-Aminophenoxy)benzene → 1-(4-Phenoxyphenyl)piperazine
반응식
Br[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]Br.[O:8]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([O-])([O-])=O.[Na+].[Na+]>CO>[O:8]([C:15]1[CH:16]=[CH:17][C:18]([N:19]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:20][CH:21]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1참가 물질
5
실험 절차
To a solution of 62.4 parts of bis-(β-bromoethyl)amine dihybromide in 160 parts of methanol there were added 37 parts of para-phenoxyaniline. The mixture was refluxed for 10 hours. 10.6 parts of Na2CO3 were then added and the reaction mixture was refluxed for a further 10 hours. After cooling, the precipitate was filtered off, washed with 80 parts of methanol and dried.
후처리
- temperatureThe mixture was refluxed for 10 hours
- temperaturethe reaction mixture was refluxed for a further 10 hours
- temperatureAfter cooling
- filtrationthe precipitate was filtered off
- washwashed with 80 parts of methanol
- customdried
출처 및 근거
- ORD 기록
- ord-2368a7cc6aa643bf82c15e20288aef90
- 출처 데이터셋
- uspto-grants-1977_12
- 특허 번호
- US04064245
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