Hydrochloric Acid → Glyphosate

HRID 462126노트

반응식

HRID 462126 반응식
Cl.[C:2]([CH2:5][NH:6][CH2:7][P:8](=[O:15])([O:12]CC)[O:9]CC)([OH:4])=[O:3]>>[P:8]([CH2:7][NH:6][CH2:5][C:2]([OH:4])=[O:3])([OH:15])([OH:12])=[O:9]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 12633685N-[(Diethoxyphosphoryl)methyl]glycine

생성물 1

HCID 3496Glyphosate수율 62.7%

실험 절차

60 ml. of concentrated hydrochloric acid are added to 11.25 g. (0.05 moles) of diethyl N-carboxymethyl-aminomethyl-phosphonate, and the mixture is boiled for 2 hours. The reaction mixture is concentrated to one-fourth volume under a pressure of 80 to 100 mmHg., and the residue is triturated with 60 ml. of ethanol. The solid substance is filtered when cold, dissolved in 15 to 20 ml. of hot water, the solution is decolorized, cooled, and the product is precipitated with 45 ml. of acetone. 5.3-5.7 g. (62.7-67.5%) of N-phosphonomethyl-glycine are obtained.

후처리

  1. concentrationThe reaction mixture is concentrated to one-fourth volume under a pressure of 80 to 100 mmHg
  2. custom, and the residue is triturated with 60 ml
  3. filtrationThe solid substance is filtered when cold
  4. dissolutiondissolved in 15 to 20 ml
  5. temperaturecooled
  6. customthe product is precipitated with 45 ml

출처 및 근거

ORD 기록
ord-538811341d8e4ab8b2112a7961410de4
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065491

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