1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 46217

반응식

HRID 46217 반응식
[Br:1]Br.[OH:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][C:5]=1[C:14]([OH:16])=[O:15]>C(O)(=O)C>[Br:1][C:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]([OH:3])=[C:5]([C:14]([OH:16])=[O:15])[CH:6]=1

참가 물질

4

반응물 2

HCID 68441-Hydroxy-2-naphthoic acid2회HCID 24408Bromine

생성물 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid수율 92.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Bromine (6.1 mL, 120 mmol) was added to a solution of 1-hydroxy-2-naphthoic acid (compound 66, 18.9 g, 100 mmol) in glacial acetic acid (250 mL). The mixture was stirred at room temperature overnight. The resulting solid was filtered and dried in vacuo to yield the title compound (24.6 g, 92%) as a white solid.

후처리

  1. filtrationThe resulting solid was filtered
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-50e18a4d23c74d9490e3660b81c779fe
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541380B2

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