Piperidine → 2-[2-(4-Methyl-1-piperazinyl)-5-thiadiazolyl)-1-methyl-5-nitroimidazole

HRID 462235

반응식

HRID 462235 반응식
[N:1]1([N:7]2[NH:11][CH:10]=[C:9]([C:12]3[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=3)[S:8]2)[CH2:6][CH2:5]C[CH2:3][CH2:2]1.[CH3:21][N:22]1CCNCC1.N1CCCCC1>>[CH3:21][N:22]1[CH2:5][CH2:6][N:1]([N:7]2[NH:11][CH:10]=[C:9]([C:12]3[N:13]([CH3:20])[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][N:16]=3)[S:8]2)[CH2:2][CH2:3]1

참가 물질

4

반응물 3

HCID 8082PiperidineHCID 531671-MethylpiperazineHCID 213908372-(2-Piperidino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

생성물 1

HCID 213908382-[2-(4-Methyl-1-piperazinyl)-5-thiadiazolyl)-1-methyl-5-nitroimidazole

실험 절차

The preparation of the above compound is carried out in the manner described for the 2-piperidino derivative (Example 28), an equivalent of 1-methylpiperazine replacing the piperidine. The crude product is purified by recrystallization from 2-methoxyethanol and melts at 242°-244° C.

후처리

  1. customThe preparation of the above compound
  2. customThe crude product is purified by recrystallization from 2-methoxyethanol and melts at 242°-244° C.

출처 및 근거

ORD 기록
ord-174ca826ea4c410fb8561635a96caa59
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065567

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