1-(Thiazol-2-yl)piperazine → 2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole

HRID 462237

반응식

HRID 462237 반응식
CN(C)CCC[N:6]1[CH2:11][CH2:10][N:9]([N:12]2[NH:16][CH:15]=[C:14]([C:17]3[N:18]([CH3:25])[C:19]([N+:22]([O-:24])=[O:23])=[CH:20][N:21]=3)[S:13]2)[CH2:8][CH2:7]1.[S:27]1[CH:31]=[CH:30][N:29]=[C:28]1N1CCNCC1.CN(C)CCCN1CCNCC1>>[S:27]1[CH:31]=[CH:30][N:29]=[C:28]1[N:6]1[CH2:11][CH2:10][N:9]([N:12]2[NH:16][CH:15]=[C:14]([C:17]3[N:18]([CH3:25])[C:19]([N+:22]([O-:24])=[O:23])=[CH:20][N:21]=3)[S:13]2)[CH2:8][CH2:7]1

참가 물질

4

반응물 3

HCID 9118061-(Thiazol-2-yl)piperazineHCID 27362341-[3-(Dimethylamino)propyl]piperazineHCID 213908032-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole

생성물 1

HCID 213908532-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole

실험 절차

The preparation of the subject compound is carried out essentially as described for the 2-[4-(3-dimethylaminopropyl)-1-piperazinyl] derivative (Example 35), an equivalent of 1-(2-thiazolyl)piperazine replacing the 1-(3-dimethylaminopropyl)piperazine. After recrystallization from 2-methoxyethanol, the pure compound melts at 297°-300° C.

후처리

  1. customThe preparation of the subject compound
  2. customAfter recrystallization from 2-methoxyethanol

출처 및 근거

ORD 기록
ord-10dfc038fa9d47f89d1562cb38168a32
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065567

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