Water → 5-Bromo-2,4-dichlorobenzoic acid

HRID 46225

반응식

HRID 46225 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br.O>ClS(O)(=O)=O.[S]>[Br:12][C:8]1[C:9]([Cl:11])=[CH:10][C:2]([Cl:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

참가 물질

6

반응물 3

HCID 962WaterHCID 57872,4-Dichlorobenzoic Acid2회HCID 24408Bromine

생성물 1

HCID 218625655-Bromo-2,4-dichlorobenzoic acid수율 187.5%

시약·촉매·용매 2

HCID 5362487Sulfur촉매HCID 24638Chlorosulfonic acid용매

반응 조건

온도
70 °C

실험 절차

To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.

후처리

  1. temperaturecooled to ambient temperature
  2. customThe resulting solid was isolated by filtration
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-541340427c5d4696b208240ea8e76d24
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541380B2

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