Benzaldehyde → 3,5-Dibenzylidene-1-(2-phenylethyl)-4-piperidone monohydrochloride

HRID 462259

반응식

HRID 462259 반응식
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[ClH:24]>C(O)C>[ClH:24].[CH:16](=[C:11]1[C:12](=[O:15])[C:13](=[CH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:14][N:9]([CH2:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:10]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 96437N-Phenethyl-4-piperidinone

생성물 1

HCID 681188373,5-Dibenzylidene-1-(2-phenylethyl)-4-piperidone monohydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Twenty-five grams of 1-(2-phenylethyl)-4-piperidone and 38 g of benzaldehyde are reacted in 180 ml of ethanol in the presence of 40 ml of concentrated hydrochloric acid at reflux temperature for about 5 hours and left at room temperature for about 16 hours yielding 25.5 g of material, melting point 217°-220° C, dec. Crystallization from 50 ml of hot dimethylformamide and 100 ml of acetonitrile yields 22 g of the title compound, melting point 225°-227° C, dec.

후처리

  1. temperatureat reflux temperature for about 5 hours

출처 및 근거

ORD 기록
ord-b0b857edc23e4ecdb0e73d1f4d1d7e60
출처 데이터셋
uspto-grants-1977_12
특허 번호
US04065617

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