C(=O)([O-])[O-].[Na+].[Na+].C(O)(=O)C(O)=O.[CH3:13][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][SH:23])=[CH:19][CH:18]=1)[CH3:15].S(S([O-])=O)([O-])=O.[Na+].[Na+].[OH:32][CH2:33][CH2:34][NH:35][C:36](=[CH:40][N+:41]([O-:43])=[O:42])[N:37]1[CH2:39][CH2:38]1>O.CO.C(OCC)C>[CH3:15][N:14]([CH2:16][C:17]1[O:21][C:20]([CH2:22][S:23][CH2:39][CH2:38][NH:37][C:36]([NH:35][CH2:34][CH2:33][OH:32])=[CH:40][N+:41]([O-:43])=[O:42])=[CH:19][CH:18]=1)[CH3:13]Ethyl ether (15 ml) and an excess of anhydrous sodium carbonate were added to a mixture in water of 0.13 g (0.5 mmole) of 5-[(dimethylamino)methyl]-2-furanmethanethiol oxalate (1:1), sodium dithionite (0.05 g) and anhydrous sodium carbonate (0.15 g). The mixture was filtered and the filtrate was evaporated under vacuum. 0.087 g (0.5 mmole) of N-(2-hydroxyethyl)-alpha-(nitromethylene)-1-aziridinemethaneamine and 4 ml of methanol were added to the residue. The mixture was evaporated to dryness and the residue was heated to 95°-100° C. for 1 hour and chromatographed over silica (methanol-0.88 NH3 ; 79:1). The appropriate eluate was evaporated under vacuum to give 0.12 g of N-[2-[[(5-[(dimethylamino)methyl]-2-furanyl)methyl]thio]ethyl]-N'-(2-hydroxyethyl)-2-nitro-1,1-ethenediamine having the same properties as the product prepared according to Example 1, paragraph (a).
불러오는 중…
