Water → 2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid

HRID 462660

반응식

HRID 462660 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]([CH:21]([CH3:23])[CH3:22])[C:16]([O:18]CC)=[O:17].O>C(O)C>[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]([CH:21]([CH3:23])[CH3:22])[C:16]([OH:18])=[O:17]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 20283987Ethyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate

생성물 1

HCID 39476432-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid수율 90%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 0.60 grams of sodium hydroxide dissolved in 10 ml of ethanol was added 3.30 g of the above ester. The mixture was stirred at room temperature for 4 hours, after which water was added, and the mixture was washed with toluene. The organic phase was discarded. The product was acidified, extracted into ether, washed with water, dried and solvent removed to yield 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid, m.p. 132°-135°, in 90% yield.

후처리

  1. washthe mixture was washed with toluene
  2. extractionextracted into ether
  3. washwashed with water
  4. customdried
  5. customsolvent removed

출처 및 근거

ORD 기록
ord-ae7e67b2425643fa8e174fc101f32af8
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04517130

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