Dibromoacetic Acid → 5-Methyl-6-nicotinoyl-1,3-benzodioxole-2-carboxylic acid

HRID 462685

반응식

HRID 462685 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[O:11])[C:5]([CH3:9])=[CH:6][C:7]=1[OH:8].Br[CH:19](Br)[C:20]([OH:22])=[O:21]>CS(C)=O.O>[CH3:9][C:5]1[C:4]([C:10](=[O:11])[C:12]2[CH:17]=[CH:16][CH:15]=[N:14][CH:13]=2)=[CH:3][C:2]2[O:1][CH:19]([C:20]([OH:22])=[O:21])[O:8][C:7]=2[CH:6]=1

참가 물질

4

반응물 2

HCID 12433Dibromoacetic AcidHCID 20396981(3,4-Dihydroxy-6-methylphenyl)-(3-pyridyl)-methanone

생성물 1

HCID 221559905-Methyl-6-nicotinoyl-1,3-benzodioxole-2-carboxylic acid

시약·촉매·용매 1

HCID 23503278(Methanesulfinyl)methane--water (1/1)용매

실험 절차

By reaction of 17.3 g (0.075 mol) of (3,4-dihydroxy-6-methylphenyl)-(3-pyridyl)-methanone with 16.5 g (0.075 mol) of dibromoacetic acid, analogously to Example 3, there is obtained 5-methyl-6-nicotinoyl-1,3-benzodioxole-2-carboxylic acid as sand-coloured crystals, m.p. 250°-232° C. (from dimethyl sulfoxide/water).

출처 및 근거

ORD 기록
ord-fb12de9e08f84669b438d02503898394
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04517184

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