Pyridine → 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide
반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.N1C=CC=CC=1.[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl>[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1)(=[O:23])=[O:22]참가 물질
5
실험 절차
To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+
후처리
- concentrationwas concentrated
- custompurified by flash column chromatography
- washeluting with hexane/ethyl acetate
출처 및 근거
- ORD 기록
- ord-b083043d358544dcbd3734bbd645a5dc
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08541588B2
반응 노트
불러오는 중…