Pyridine → 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide

HRID 46290

반응식

HRID 46290 반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.N1C=CC=CC=1.[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl>[F:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1)(=[O:23])=[O:22]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 21552-AminothiazoleHCID 27342732,4-Difluorobenzenesulfonyl Chloride

생성물 1

HCID 250389042,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+

후처리

  1. concentrationwas concentrated
  2. custompurified by flash column chromatography
  3. washeluting with hexane/ethyl acetate

출처 및 근거

ORD 기록
ord-b083043d358544dcbd3734bbd645a5dc
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541588B2

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