Glutaric Acid → HCID 178512817, 화합물

HRID 462909

반응식

HRID 462909 반응식
Cl.N(CCCCCC(N)=O)C(N)=N.Cl.Cl.NCCCNCCCCNC(=O)C(O)O.C(O)(=O)CCCC(O)=O.Cl.Cl.Cl.[NH2:43][CH2:44][CH2:45][CH2:46][NH:47][CH2:48][CH2:49][CH2:50][CH2:51][NH:52][C:53](=[O:68])[CH:54]([NH:56][C:57](=[O:67])[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][NH:63][C:64]([NH2:66])=[NH:65])[OH:55]>O>[NH2:43][CH2:44][CH2:45][CH2:46][NH:47][CH2:48][CH2:49][CH2:50][CH2:51][NH:52][C:53](=[O:68])[CH:54]([NH:56][C:57](=[O:67])[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][NH:63][C:64]([NH2:66])=[NH:65])[OH:55]

참가 물질

6

반응물 4

HCID 743Glutaric AcidHCID 133564GlyoxylylspermidineHCID 178478611HCID 178478611, 화합물HCID 178479436HCID 178479436, 화합물

생성물 1

HCID 178512817HCID 178512817, 화합물수율 44%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
60 °C

실험 절차

A mixture of 446 mg (2.14 mmoles) of 6-guanidinohexanamide hydrochloride, 750 mg (2.57 mmoles) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 283 mg (2.14 mmoles) of glutaric acid and 0.45 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture and the resulting mixture was purified in a manner similar to that in Example 1, using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 459 mg (44% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(6-guanidinohexanamido)-2-hydroxyethanamide trihydrochloride.

후처리

  1. additionwas added to the reaction mixture
  2. customthe resulting mixture was purified in a manner similar to that in Example 1

출처 및 근거

ORD 기록
ord-5428e93f3522409ab46bd8ae87e26d73
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04518532

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