Hydrogen Bromide → HCID 10036524, 화합물

반응식

C(O[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11])(=O)C.O.[BrH:16]>>[Br:16][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=[O:11]

참가 물질

반응물 3

HCID 260Hydrogen Bromide

HCID 962Water

HCID 202819056-Acetoxy-2,2-dimethylhexanoic acid

생성물 1

HCID 10036524HCID 10036524, 화합물수율 91%

반응 조건

온도: 130 °C

실험 절차

6-Acetoxy-2,2-dimethylhexanoic acid (4.5 g) was dissolved in 47% aqueous hydrobromic acid (25 ml), and the solution was heated at 130° C. for 4 hours. After the completion of the reaction, water (100 ml) was added to the solution, and the product was extracted with ether. The organic layer was washed with water, dried and concentrated under reduced pressure. The residue was chromatographed on a column of silica gel, and development with isopropyl ether yielded 6-bromo-2,2-dimethylhexanoic acid (4 g, 91%).

후처리

additionwas added to the solution
extractionthe product was extracted with ether
washThe organic layer was washed with water
customdried
concentrationconcentrated under reduced pressure
customThe residue was chromatographed on a column of silica gel, and development with isopropyl ether

출처 및 근거

ORD 기록: ord-e4cfa8b1063441a49398f0ae5e38d391
출처 데이터셋: uspto-grants-1985_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04518602

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