Benzoic acid, 3-methoxy-2-nitro-, methyl ester → Methyl 2-amino-3-methoxybenzoate

HRID 463065

반응식

HRID 463065 반응식
[CH3:1][O:2][C:3]1[C:4]([N+:13]([O-])=O)=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7]>C1(C)C=CC=CC=1.[Pt]>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[C:4]=1[NH2:13]

참가 물질

4

반응물 1

HCID 79195Benzoic acid, 3-methoxy-2-nitro-, methyl ester

생성물 1

HCID 602320Methyl 2-amino-3-methoxybenzoate

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 1140Toluene용매

실험 절차

One hundred thirty-three grams (0.63 mol) of methyl 3-methoxy-2-nitro-benzoate are dissolved in 1000 ml of toluene and hydrogenated in an autoclave at ambient temperature and under a hydrogen pressure of 5 bar in the presence of platinum over a period of two hours. The catalyst is removed by filtration, the residue is dried with sodium sulfate, and the toluene is distilled off in vacuo. Oil, RF value: 0.8 [silica gel plate; chloroform/acetone (9:1)],

후처리

  1. customhydrogenated in an autoclave at ambient temperature and under a hydrogen
  2. customof two hours
  3. customThe catalyst is removed by filtration
  4. dry with materialthe residue is dried with sodium sulfate
  5. distillationthe toluene is distilled off in vacuo

출처 및 근거

ORD 기록
ord-b6f69015d892488a930568c8d1363b2b
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04518597

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