Ethylenediamine → N-(2-aminoethyl)thiophene-2-carboxamide
반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8]CC)=O.[CH2:11]([NH2:14])[CH2:12][NH2:13]>C1(C)C=CC=CC=1>[NH2:13][CH2:12][CH2:11][NH:14][C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:8]참가 물질
4
실험 절차
A mixture of ethyl thiophene-2-carboxylate (12.0 g.) and ethylenediamine (15.4 ml.) was heated at 95°-100° C. for 48 hours. Excess ethylenediamine was removed under reduced pressure and the residue was dissolved in water (150 ml.). The insoluble material [bis(carboxamide)derivative] was removed by filtration. Evaporation of the filtrate gave a residue which was dissolved in toluene (50 ml.). The mixture was evaporated to give N-(2-aminoethyl)-thiophene-2-carboxamide as an oil (12.0 g.) essentially pure by TLC (Rf 0.90; SiO2 : 10% v/v methanol in chloroform as eluant) which was used without purification.
후처리
- temperaturewas heated at 95°-100° C. for 48 hours
- customExcess ethylenediamine was removed under reduced pressure
- dissolutionthe residue was dissolved in water (150 ml.)
- customThe insoluble material [bis(carboxamide)derivative] was removed by filtration
- customEvaporation of the filtrate
- customgave a residue which
- customThe mixture was evaporated
출처 및 근거
- ORD 기록
- ord-bb725bcb229f4b24a4de4c9fd9359245
- 출처 데이터셋
- uspto-grants-1985_05
- 특허 번호
- US04520027
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