Sodium Hydroxide → 4-[(Methylsulfonyl)amino]benzoic acid sodium salt

HRID 463672

반응식

HRID 463672 반응식
[OH-].[Na+:2].[CH3:3][S:4]([NH:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]>O>[Na+:2].[CH3:3][S:4]([NH:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([O-:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 2506534-(Methylsulfonamido)benzoic acid

생성물 1

HCID 236984714-[(Methylsulfonyl)amino]benzoic acid sodium salt수율 97.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 500 ml of water is added 63.4 g (1.59 mole) of sodium hydroxide and the mixture is stirred until all the solid has dissolved. To this is slowly added 310 g (1.44 mole) of 4-[(methylsulfonyl)amino]benzoic acid. The reaction is stirred for 15 minutes at ambient temperature after all the solid has dissolved. After removal of the water in vacuo, the residue is triturated with isopropyl alcohol, evaporated, triturated with acetone and concentrated in vacuo. The solid is dried under vacuum for 72 hours to provide 333.7 g of the title compound.

후처리

  1. dissolutionhas dissolved
  2. stirringThe reaction is stirred for 15 minutes at ambient temperature after all the solid
  3. dissolutionhas dissolved
  4. customAfter removal of the water in vacuo
  5. customthe residue is triturated with isopropyl alcohol
  6. customevaporated
  7. customtriturated with acetone
  8. concentrationconcentrated in vacuo
  9. customThe solid is dried under vacuum for 72 hours

출처 및 근거

ORD 기록
ord-d3aec6aa7e4f4b75b813675422581f18
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544654

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