3-Chloro-6-hydroxyacetophenone → (E)-1-(5-chloro-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 46369

반응식

HRID 46369 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CC(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([C:8](=[O:10])/[CH:9]=[CH:14]/[N:15]([CH3:17])[CH3:16])[CH:7]=1

참가 물질

4

반응물 2

HCID 740613-Chloro-6-hydroxyacetophenoneHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 33728788(E)-1-(5-chloro-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one수율 72%

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
45 °C

실험 절차

To a solution of 1-(5-chloro-2-hydroxyphenyl)ethanone (17.2 g, 100.8 mmol) in propan-2-ol (100 ml) was added 1,1-dimethoxy-N,N-dimethylmethanamine (27 ml, 200 mmol) dropwise and the reaction mixture was warmed to 45° C. and stirred for 24 hours. The resulting suspension was cooled in ice, filtered and washed with propan-2-ol then tert-butyl methyl ether. The solid was dried in vacuo to give the title compound as a bright yellow solid, 16.39 g, 72% yield.

후처리

  1. temperatureThe resulting suspension was cooled in ice
  2. filtrationfiltered
  3. washwashed with propan-2-ol
  4. customThe solid was dried in vacuo

출처 및 근거

ORD 기록
ord-8c94de01153b46b79422b55180ac0bde
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541588B2

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