Chloroacetaldehyde → 10-Methyl-9-[2-(1,3-thiazol-2-yl)hydrazinylidene]-9,10-dihydroacridine--hydrogen chloride (1/1)

HRID 463691노트

반응식

HRID 463691 반응식
[CH3:1][N:2]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[N:16][NH:17][C:18]([NH2:20])=[S:19])[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[Cl:21][CH2:22][CH:23]=O>CO>[ClH:21].[S:19]1[CH:23]=[CH:22][N:20]=[C:18]1[NH:17][N:16]=[C:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[N:2]([CH3:1])[C:3]2[C:8]1=[CH:7][CH:6]=[CH:5][CH:4]=2

참가 물질

4

반응물 2

HCID 33ChloroacetaldehydeHCID 5201653HCID 5201653, 화합물

생성물 1

HCID 2483272110-Methyl-9-[2-(1,3-thiazol-2-yl)hydrazinylidene]-9,10-dihydroacridine--hydrogen chloride (1/1)

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.9 g of 10-methyl-9acridanone thiosemicarbazone are suspended in 100 ml of methanol and stirred at 50° for 6 hours with 1.73 ml of chloroacetaldehyde (50percent aqueous solution). The mixture is concentrated, the crystalline product is filtered and washed successively with ethanol, water, ethanol and ether. There is obtained 10-methyl-9-acridanone (2-thiazolyl)hydrazone hydrochloride of melting point 224°-225° (decomposition).

후처리

  1. concentrationThe mixture is concentrated
  2. filtrationthe crystalline product is filtered
  3. washwashed successively with ethanol, water, ethanol and ether

출처 및 근거

ORD 기록
ord-aa47c8a0a0c044e287f215bea23de30f
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544659

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