Thionyl Chloride → 5-Methyl-3-phenylisoxazole-4-carbonyl chloride

HRID 463785

반응식

HRID 463785 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13](C(O)=O)=[O:14].S(Cl)([Cl:20])=O>N1C=CC=CC=1>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([Cl:20])=[O:14]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 202651525-Methyl-3-phenyl-4-isoxazoloyl carboxylic acid

생성물 1

HCID 856245-Methyl-3-phenylisoxazole-4-carbonyl chloride

시약·촉매·용매 1

HCID 1049Pyridine촉매

실험 절차

A mixture of 111.76 g of 5-methyl-3-phenyl-4-isoxazoloyl carboxylic acid, 6 drops of pyridine and 29.5 ml of thionyl chloride is stirred under reflux for 4 hrs. The excess thionyl chloride is evaporated in vacuo. Distillation of the residue yields 113.74 g of yellow liquid.

후처리

  1. temperatureunder reflux for 4 hrs
  2. customThe excess thionyl chloride is evaporated in vacuo
  3. distillationDistillation of the residue

출처 및 근거

ORD 기록
ord-e5e56676ef5d48e9b65a67a4cd85f5d8
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04544670

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