Chlorodifluoromethane → 2-Amino-4-chloro-6-difluoromethoxy-pyrimidine
반응식
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[O:10]1CCOCC1.[F:16][CH:17]([F:19])Cl>[OH-].[Na+]>[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([O:10][CH:17]([F:19])[F:16])[N:3]=1참가 물질
5
실험 절차
A suspension of 16.4 g of 2-amino-4,6-dichloropyrimidine in 100 ml of 40% sodium hydroxide solution is stirred at a temperature of 95°-100° C. for 1 hour. 200 ml of dioxane are added, and 20 g of gaseous difluorochloromethane are passed in at a temperature of 70°-75° C. in the course of 1 hour. The organic phase is separated off and concentrated to about 1/5 of its volume, the residue is poured into water and the solid precipitate is separated off to give 6 g of 2-amino-4-chloro-6-difluoromethoxy-pyrimidine of melting point 118°-119° C.
후처리
- customare passed in at a temperature of 70°-75° C. in the course of 1 hour
- customThe organic phase is separated off
- concentrationconcentrated to about 1/5 of its volume
- additionthe residue is poured into water
- customthe solid precipitate is separated off
출처 및 근거
- ORD 기록
- ord-3d7970ddaca4471cbf5c4a4dd3c6762e
- 출처 데이터셋
- uspto-grants-1985_10
- 특허 번호
- US04545811
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