Chlorine → 3-Chloro-5-(trifluoromethyl)pyridin-2-ol
반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1.[Cl:12]Cl>C(Cl)(Cl)Cl>[Cl:12][C:5]1[C:6](=[O:9])[NH:7][CH:8]=[C:3]([C:2]([F:1])([F:10])[F:11])[CH:4]=1참가 물질
4
실험 절차
[A] 0.2 g of 5-trifluoromethyl-2-pyridone was dissolved in 20 ml of chloroform, and chlorine gas was pressed through the solution at 50° C. for 1 hour while stirring. After completion of the reaction, the chloroform was distilled off, and recrystallization was performed from a mixed solvent of toluene and n-hexane to obtain 0.15 g of the titled compound having a melting point of 144° to 147° C. The recrystallization was further repeated to obtain 0.09 g of the titled compound having a melting point of 165° to 166° C.
후처리
- customAfter completion of the reaction
- distillationthe chloroform was distilled off
- customrecrystallization
출처 및 근거
- ORD 기록
- ord-3d65025180d541d09500a4a4ae4da374
- 출처 데이터셋
- uspto-grants-1985_10
- 특허 번호
- US04546191
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