Chlorine → 3-Chloro-5-(trifluoromethyl)pyridin-2-ol

HRID 464127

반응식

HRID 464127 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6](=[O:9])[NH:7][CH:8]=1.[Cl:12]Cl>C(Cl)(Cl)Cl>[Cl:12][C:5]1[C:6](=[O:9])[NH:7][CH:8]=[C:3]([C:2]([F:1])([F:10])[F:11])[CH:4]=1

참가 물질

4

반응물 2

HCID 24526ChlorineHCID 1474432-Hydroxy-5-(trifluoromethyl)pyridine

생성물 1

HCID 7254363-Chloro-5-(trifluoromethyl)pyridin-2-ol

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

[A] 0.2 g of 5-trifluoromethyl-2-pyridone was dissolved in 20 ml of chloroform, and chlorine gas was pressed through the solution at 50° C. for 1 hour while stirring. After completion of the reaction, the chloroform was distilled off, and recrystallization was performed from a mixed solvent of toluene and n-hexane to obtain 0.15 g of the titled compound having a melting point of 144° to 147° C. The recrystallization was further repeated to obtain 0.09 g of the titled compound having a melting point of 165° to 166° C.

후처리

  1. customAfter completion of the reaction
  2. distillationthe chloroform was distilled off
  3. customrecrystallization

출처 및 근거

ORD 기록
ord-3d65025180d541d09500a4a4ae4da374
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04546191

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