2,3-Dichloroquinoxaline → 2-Chloro-3-hydrazinoquinoxaline

HRID 464279

반응식

HRID 464279 반응식
[Cl:1][C:2]1[C:11](Cl)=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.O.[NH2:14][NH2:15]>C(O)C>[Cl:1][C:2]1[C:11]([NH:14][NH2:15])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 166592,3-DichloroquinoxalineHCID 24654Hydrazine hydrate (1:1)

생성물 1

HCID 36588202-Chloro-3-hydrazinoquinoxaline수율 41%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2,3-Dichloroquinoxaline (33.5 g., 0.168 mole) was stirred with hydrazine hydrate (18.5 g., 0.369 mole) in 500 ml. of ethanol at room temperature overnight (i.e.. at ca. 20° C. for approximately 16 hours). The thick, yellow slurry was filtered and the precipitate was washed with ethanol. The precipitated material was recrystallized from hot methanol to give 13.5 g. (41% yield) of 2-chloro-3-hydrazinoquinoxaline, m.p. 181° C. (decomp.). Mass spectrum: m/e, 194 (P).

후처리

  1. customat room temperature
  2. customovernight (i.e.. at ca. 20° C. for approximately 16 hours)
  3. filtrationThe thick, yellow slurry was filtered
  4. washthe precipitate was washed with ethanol
  5. customThe precipitated material was recrystallized from hot methanol
  6. customto give 13.5 g

출처 및 근거

ORD 기록
ord-a221652dd3ff4eb0a45c35470f69b1ee
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04547501

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