Ethyl orthoformate → 4-Chloro[1,2,4]triazolo[4,3-a]quinoxaline

반응식

[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH:14](OCC)(OCC)OCC>>[Cl:1][C:2]1[C:11]2[N:10]([CH:14]=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[CH:7][CH:8]=2

참가 물질

반응물 2

HCID 31214Ethyl orthoformate

HCID 36588202-Chloro-3-hydrazinoquinoxaline

생성물 1

HCID 11261184-Chloro[1,2,4]triazolo[4,3-a]quinoxaline수율 94%

실험 절차

2-Chloro-3-hydrazinoquinoxaline (9.0 g., 0.046 mole) the product of Example 1, was stirred with triethyl orthoformate (90 ml.) at 100° C. for one hour. The mixture was cooled to room temperature and the solid precipitate was collected by filtration and washed with cyclohexane and dried to afford 8.8 g. (94% yield) of 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 287°-290° C. (decomp.). Mass spectrum: m/e, 204 (P).

후처리

filtrationthe solid precipitate was collected by filtration
washwashed with cyclohexane
customdried
customto afford 8.8 g

출처 및 근거

ORD 기록: ord-70b80ffed64d497681be598e3df21903
출처 데이터셋: uspto-grants-1985_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04547501

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