HCID 13373474, 화합물 → 2-[3-(N-benzyl-N-pyrid-2-ylamino)propylamino]-5-pyrid-4-ylmethylpyrimid-4-one

HRID 464374

반응식

HRID 464374 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N+](N[C:23]1[NH:28][C:27](=[O:29])[C:26]([CH2:30][C:31]2[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=2)=[CH:25][N:24]=1)([O-])=O>N1C=CC=CC=1>[CH2:6]([N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:23]1[NH:28][C:27](=[O:29])[C:26]([CH2:30][C:31]2[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=2)=[CH:25][N:24]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 13373474HCID 13373474, 화합물HCID 201503642-[N-(3-aminopropyl)-N-benzylamino)pyridine

생성물 1

HCID 202628912-[3-(N-benzyl-N-pyrid-2-ylamino)propylamino]-5-pyrid-4-ylmethylpyrimid-4-one

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-[N-(3-aminopropyl)-N-benzylamino)pyridine (1.0 g) and 2-nitroamino-5-(pyrid-4-ylmethyl)pyrimid-4-one (0.68 g) were heated together under reflux in pyridine (2.5 ml) for 23 hr. After stripping the residue was twice crystallized from ethanol/water to give 2-[3-(N-benzyl-N-pyrid-2-ylamino)propylamino]-5-pyrid-4-ylmethylpyrimid-4-one 1.6 H2O, 0.86 g (68%) m.p. 87°-89° C.

후처리

  1. customwas twice crystallized from ethanol/water

출처 및 근거

ORD 기록
ord-7ed901a7345a4bd2ba1887c458807b33
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04547506

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