Bromine → Maltol
반응식
[C:1]([C:4]1[O:5][CH:6]=[CH:7][C:8]=1Cl)(=[O:3])[CH3:2].[BH4-].[Na+].[OH:12]C(C1OC=CC=1Cl)C.BrBr>CO.O>[CH3:8][C:4]1[O:5][CH:6]=[CH:7][C:2](=[O:12])[C:1]=1[OH:3]참가 물질
7
반응 조건
- 온도
- 25 °C
실험 절차
2-Acetyl-3-chloro-furan (1.0 g, 7 mmoles) in 30 ml methanol was cooled to 10° C. and 0.065 g, (1.7 mmoles) of NaBH4 added in one portion. After stirring for 30 minutes at 25° C., the solution was treated with 15 ml of water and cooled to 5° C. To the formed 2-(1-hydroxyethyl)-3-chloro-furan was then added 1.1 g (7 mmoles) of bromine, dropwise and with cooling. After the addition was complete the reaction was heated to 95° C. for 2 hours, distilling off a portion of the methanol. The reaction was then cooled and maltol isolated by the method of Example 1.
후처리
- temperaturecooled to 5° C
- temperaturedropwise and with cooling
- additionAfter the addition
- temperaturewas heated to 95° C. for 2 hours
- distillationdistilling off a portion of the methanol
- temperatureThe reaction was then cooled
출처 및 근거
- ORD 기록
- ord-636529bf8c044b80ad25cd39db528472
- 출처 데이터셋
- uspto-grants-1979_11
- 특허 번호
- US04173572
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