Hydrogen Peroxide → 2-(p-Chlorobenzylidene)-1-indanone oxide

HRID 46475

반응식

HRID 46475 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH:6]=[C:7]2[CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]2=[O:16])=[CH:4][CH:3]=1.[OH:19]O.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:6]=[C:7]2[CH2:15][C:14]34[O:19][CH:13]3[CH:12]=[CH:11][CH:10]=[C:9]4[C:8]2=[O:16])=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 3672172-(p-Chlorobenzylidene)-1-indanone

생성물 1

HCID 867366912-(p-Chlorobenzylidene)-1-indanone oxide

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

Ten grams (0.039 mole) of 2-(p-chlorobenzylidene)-1-indanone is converted to the epoxide in 1 liter of MeOH, using 9.6 g (0.085 mole) of 30% H2O2 and 9.6 ml (0.039 mole) of 16% NaOH, as described in Example 1. Since the starting material is poorly soluble in MeOH it is oxidized as a suspension and the product separates during the course of the reaction (5 hours at 35°-38°). The crude yield is 10 g (94%); m.p. 162°-164°. Crystallization (of 9.7 g) from 70 ml of MeCN gives 8.8 g (86%) of nearly colorless solid; m.p. 165°-167°.

후처리

  1. customthe product separates during the course of the reaction (5 hours at 35°-38°)
  2. customCrystallization (of 9.7 g) from 70 ml of MeCN
  3. customgives 8.8 g (86%) of nearly colorless solid

출처 및 근거

ORD 기록
ord-594ea544cd3e4ecf976a92c8aafa37d0
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04173634

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