3-Hydroxybenzaldehyde → 3-[(3-Methylpiperidin-1-yl)methyl]phenol

HRID 4648

반응식

HRID 4648 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1.C(O)=O.N>O>[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][N:13]([CH2:5][C:4]2[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=2)[CH2:12]1

참가 물질

6

반응물 4

HCID 1013-HydroxybenzaldehydeHCID 222AmmoniaHCID 284Formic AcidHCID 790813-Methylpiperidine

생성물 1

HCID 133646663-[(3-Methylpiperidin-1-yl)methyl]phenol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.

후처리

  1. temperaturewith cooling
  2. temperatureWhen the reaction mixture has cooled to room temperature
  3. filtrationthe precipitated solid is filtered off
  4. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-e9c53b21b5524c4296badbb52530d5b3
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727081

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