3-Hydroxybenzaldehyde → 3-[(3-Methylpiperidin-1-yl)methyl]phenol
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1.C(O)=O.N>O>[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][N:13]([CH2:5][C:4]2[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=2)[CH2:12]1참가 물질
6
반응 조건
- 온도
- 120 °C
실험 절차
24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.
후처리
- temperaturewith cooling
- temperatureWhen the reaction mixture has cooled to room temperature
- filtrationthe precipitated solid is filtered off
- customrecrystallised from ethanol
출처 및 근거
- ORD 기록
- ord-e9c53b21b5524c4296badbb52530d5b3
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04727081
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