Water → 2,3-Epoxypropyl 3-methylflavone-8-carboxylate

HRID 464981노트

반응식

HRID 464981 반응식
[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[O:22]1[CH2:26][CH:23]1[CH2:24]O.C(N(CC)CC)C.O>C1C=CC=CC=1>[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([O:15][CH2:24][CH:23]3[O:22][CH2:26]3)=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 11164GlycidolHCID 770163-Methylflavone-8-carboxylic acid

생성물 1

HCID 102463862,3-Epoxypropyl 3-methylflavone-8-carboxylate수율 75.2%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

21.3 g of 3-methylflavone-8-carboxylic acid were slowly added, over a period of 4 hours at 20° C., to a stirred solution of 5.55 g of 2,3-epoxy-1-propanol and 8.34 g of triethylamine in 165 ml of anhydrous benzene. The mixture was permitted to stand at 20°-25° C. for 20 hours, and then 60 ml of water were added. The entire reaction mass was stirred for 15 minutes and the layers were separated. The organic layer was washed and dried, the solvent was evaporated off and 18.95 g of 2,3-epoxypropyl 3-methylflavone-8-carboxylate, m.p. 103°-105° C., were obtained.

후처리

  1. customthe layers were separated
  2. washThe organic layer was washed
  3. customdried
  4. customthe solvent was evaporated off

출처 및 근거

ORD 기록
ord-07777b7bc34747e9855f4006a88dbfee
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550115

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