2-(Morpholinomethyl)-pyridine → 4-((Piperidin-2-yl)methyl)morpholine

HRID 465050노트

반응식

HRID 465050 반응식
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>C(O)(=O)C.[Pt](=O)=O>[N:1]1([CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][NH:9]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 2696942-(Morpholinomethyl)-pyridineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 31633954-((Piperidin-2-yl)methyl)morpholine수율 52.2%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 176Acetic Acid용매

실험 절차

First, 2-[(4-morpholinyl)methyl]pyridine (94.0 g, 0.53 mol) is dissolved in glacial acetic acid (600 ml) and hydrogenated in the presence of platinum(IV) oxide (10.0 g) as catalyst for 2 hours at a hydrogen pressure of 3 bar and a temperature of 50° C. After cooling, the catalyst is filtered off, the filtrate is freed from solvent and the residue is distilled in vacuo. The desired compound (51.0 g) is obtained in the form of a colorless liquid, boiling point 4 mm Hg 91°-92° C.

후처리

  1. customa temperature of 50° C
  2. temperatureAfter cooling
  3. filtrationthe catalyst is filtered off
  4. distillationthe residue is distilled in vacuo

출처 및 근거

ORD 기록
ord-6c56b257a38d47f38fb5eebc01b1ff4f
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550107

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