Dimethyl-(2-piperidin-2-yl-ethyl)-amine → 5,10-Dihydro-5-[[2-[2-(dimethylamino)ethyl]-1-piperidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

HRID 465061

반응식

HRID 465061 반응식
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[CH:20][C:6]1=2)=[O:4].[CH3:21][N:22]([CH3:31])[CH2:23][CH2:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][NH:26]1>C(#N)C>[CH3:31][N:22]([CH3:21])[CH2:23][CH2:24][CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][N:26]1[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[CH:20][C:6]1=2)=[O:4]

참가 물질

4

반응물 2

HCID 296295Dimethyl-(2-piperidin-2-yl-ethyl)-amineHCID 100854195-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

생성물 1

HCID 135785595,10-Dihydro-5-[[2-[2-(dimethylamino)ethyl]-1-piperidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The title compound is prepared analogously to Example 2 from 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2-[2-(dimethylamino)ethyl]piperidine to give colorless crystals, mp. 155°-157° C. (acetonitrile).

출처 및 근거

ORD 기록
ord-60e390bd0a8b45b6a7d430164a616997
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550107

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