Ethyl orthoformate → 7-(2-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

HRID 465122노트

반응식

HRID 465122 반응식
[NH:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[CH:15](OCC)(OCC)OCC>>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:7]1[CH:6]=[CH:5][N:4]2[CH:15]=[N:2][N:1]=[C:3]2[CH:8]=1

참가 물질

3

반응물 2

HCID 31214Ethyl orthoformateHCID 135337172'-Hydrazino-2,4'-bipyridine

생성물 1

HCID 135337087-(2-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

실험 절차

A mixture of 2.0 g of 2'-hydrazino-2,4'-bipyridine and 50 ml of triethyl orthoformate was heated on a steam bath for 18 hours then chilled and filtered. The crystals were dissolved in methylene chloride, treated with activated carbon, filtered and the filtrate concentrated. Chilling and filtration gave 1.5 g of the desired product as cream colored crystals, mp 144-°145° C.

후처리

  1. temperaturewas heated on a steam bath for 18 hours
  2. temperaturethen chilled
  3. filtrationfiltered
  4. dissolutionThe crystals were dissolved in methylene chloride
  5. additiontreated with activated carbon
  6. filtrationfiltered
  7. concentrationthe filtrate concentrated
  8. temperatureChilling
  9. filtrationfiltration

출처 및 근거

ORD 기록
ord-1ff8877b5ac34ea2b3950340a906c49d
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550166

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