Hydrochloric Acid → 7-(3-Pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride

HRID 465374노트

반응식

HRID 465374 반응식
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[CH:23]=[C:22]3[C:17]([C:18](=[O:32])[C:19]([C:27]([O:29]CC)=[O:28])=[CH:20][N:21]3[CH:24]3[CH2:26][CH2:25]3)=[CH:16][C:15]=2[F:33])[CH2:9]1)=O)(C)(C)C.[ClH:34]>C(O)(=O)C>[ClH:34].[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[CH:23]=[C:22]3[C:17]([C:18](=[O:32])[C:19]([C:27]([OH:29])=[O:28])=[CH:20][N:21]3[CH:24]3[CH2:26][CH2:25]3)=[CH:16][C:15]=2[F:33])[CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 15021537Ethyl 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-6-fluoro1,4-dihydro-4-oxoquinoline-3-carboxylate

생성물 1

HCID 679157567-(3-Pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Ethyl 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3carboxylate (210 mg) was dissolved in a mixture consisting of 0.7 ml of concentrated hydrochloric acid and 2.8 ml of acetic acid. The resulting solution was heated under reflux for 3 hours. The reaction mixture was concentrated to dryness under reduced pressure. The residue was recrystallized from ethanol, whereby 60 mg of the title compound was obtained as crystals.

후처리

  1. temperatureThe resulting solution was heated
  2. temperatureunder reflux for 3 hours
  3. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  4. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-7677fad717f24058a18f08e23d6b4e87
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153203

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