Potassium Iodide → 3,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone

HRID 465448노트

반응식

HRID 465448 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:15])[NH:12][C:13]=2[CH3:14])=[CH:4][CH:3]=1.Cl[CH2:17][C:18](=[O:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CC(C)=O>[CH2:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH2:9][CH2:10][C:11](=[O:15])[NH:12][C:13]=2[CH3:14])=[CH:6][CH:7]=1)[C:18]([CH3:19])=[O:20]

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 132689765-(4-Hydroxyphenyl)-6-methyl-3,4-dihydropyridin-2(1H)-one

생성물 1

HCID 198745663,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3,4-dihydro-5-(4-hydroxyphenyl)-6-methyl-2(1H)-pyridinone (0.94 g), chloroacetone (0.43 g) and potassium carbonate (0.64 g), with a catalytic amount of potassium iodide, was stirred and heated under reflux in acetone (80 ml) for 16 hr. The solvent was evaporated and the residue partitioned between water and ethyl acetate. The organic layer was dried (MgSO4) and evaporated to give 3,4-dihydro-5-(4-acetonyloxyphenyl)-6-methyl-2(1H)-pyridinone as a solid.

후처리

  1. temperatureheated
  2. customThe solvent was evaporated
  3. customthe residue partitioned between water and ethyl acetate
  4. dry with materialThe organic layer was dried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-8e9de204cc9f4536ae735588dc99832d
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153210

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