Sodium borohydride → 2-Methoxycarbonyl-3-methoxycarbonylmethyl-2-(cis-2-pentenyl)-cyclopentanol

HRID 46551노트

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HRID 46551 반응식
[C:1]([O:5][C:6]([C:8]1([CH2:19]/[CH:20]=[CH:21]\[CH2:22][CH3:23])[C:12](=[O:13])[CH:11]=[CH:10][CH:9]1[CH2:14][C:15]([O:17][CH3:18])=[O:16])=[O:7])(C)(C)C.[BH4-].[Na+]>CO>[CH3:1][O:5][C:6]([C:8]1([CH2:19]/[CH:20]=[CH:21]\[CH2:22][CH3:23])[CH:9]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH2:10][CH2:11][CH:12]1[OH:13])=[O:7]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 70583183HCID 70583183, 화합물2회

생성물 1

HCID 706010102-Methoxycarbonyl-3-methoxycarbonylmethyl-2-(cis-2-pentenyl)-cyclopentanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 220 mg quantity of 5-methoxycarbonyl-4-methoxycarbonylmethyl-5-(cis-2-pentenyl)-2-cyclopentenone (compound (2-b)) and 60 mg of sodium borohydride are dissolved in 50 ml of methanol, and the solution is refluxed for one hour. The same procedure as in Example 1 is thereafter repeated, affording 2-methoxycarbonyl-3-methoxycarbonylmethyl-2-(cis-2-pentenyl)-cyclopentanol (compound (1-b), R1 =R2 =CH3) in a yield of 94.7%, b.p. 74°-78° C./0.01 mm Hg.

후처리

  1. temperaturethe solution is refluxed for one hour

출처 및 근거

ORD 기록
ord-c5282019786c43e2ad0bdcea505c5eb3
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04173707

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