Diethyl Malonate → Diethyl 2-pent-4-enylpropanedioate

HRID 465543

반응식

HRID 465543 반응식
[Na].[C:2]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].Br[CH2:14][CH2:15][CH2:16][CH:17]=[CH2:18]>C(O)C>[CH2:18]([CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:2]([O:10][CH2:11][CH3:12])=[O:9])[CH2:17][CH2:16][CH:15]=[CH2:14]

참가 물질

5

반응물 3

HCID 7761Diethyl MalonateHCID 707041-Pentene, 5-bromo-HCID 5360545Sodium

생성물 1

HCID 361718Diethyl 2-pent-4-enylpropanedioate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 300 ml of ethanol are added 5 g of sodium spheres and after a clear solution is obtained, 32.1 g of diethyl malonate is added in one portion. After 1 h at room temperature, 15 g of 5-bromopent-1-ene is added and the reaction mixture is stirred at room temperature for 16 h. The reaction mixture is evaporated to dryness and the residue is distilled under high vacuum to obtain diethyl pent-4-enylmalonate.

후처리

  1. customafter a clear solution is obtained
  2. customThe reaction mixture is evaporated to dryness
  3. distillationthe residue is distilled under high vacuum

출처 및 근거

ORD 기록
ord-eab5d11f5c06433ca30c1f73b2b051f1
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153214

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