Acetic Anhydride → N-[2-[[2,6-bis(1-Methylethyl)phenyl]amino]-2-oxoethyl]-N-(diphenylmethyl)-2,2,3,3,4,4,4-heptafluorobutanamide

HRID 465661

반응식

HRID 465661 반응식
[CH3:1][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[NH:13][C:14](=[O:30])[CH2:15][NH:16][CH:17]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:3].CC(C1C=CC=C(C(C)C)C=1NC(=O)CNC(C)(C)CC1C=CC=CC=1)C.FC(F)(F)C(F)(F)C(F)(F)C([O:64][C:65](=O)[C:66]([F:75])([F:74])[C:67]([F:73])([F:72])[C:68]([F:71])([F:70])[F:69])=O.C(OC(=O)C)(=O)C>>[CH3:3][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:11])[CH3:12])[C:5]=1[NH:13][C:14](=[O:30])[CH2:15][N:16]([CH:17]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:65](=[O:64])[C:66]([F:74])([F:75])[C:67]([F:72])([F:73])[C:68]([F:71])([F:70])[F:69])[CH3:1]

참가 물질

5

반응물 4

HCID 7918Acetic AnhydrideHCID 67643Heptafluorobutyric anhydrideHCID 1645639N-[2,6-bis(1-Methylethyl)phenyl]-2-[(diphenylmethyl)amino]acetamideHCID 19874910N-[2,6-bis(1-Methylethyl)phenyl]-2-[(1,1-dimethyl-2-phenylethyl)amino]acetamide

생성물 1

HCID 19874870N-[2-[[2,6-bis(1-Methylethyl)phenyl]amino]-2-oxoethyl]-N-(diphenylmethyl)-2,2,3,3,4,4,4-heptafluorobutanamide

실험 절차

When in the procedure of Example 79 an appropriate amount of the product of Example 4 was substituted for the product of Example 5 and an appropriate amount of heptafluorobutyric anhydride was substituted for acetic anhydride and the general procedure of Example 79 was followed the title compound was obtained. Total yield, 1.33 g (59%).

출처 및 근거

ORD 기록
ord-dc87ba1364ec41c1901f800b265ed00b
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153226

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